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Clinical Oncology

Human leukocyte antigen (HLA) is a protein-or marker-found on most cells in humans and is used to match with a donor for organ, bone marrow or cord blood transplants. HLAs correspond to major histocompatibility complex (MHC) proteins in humans with six genes (three from each parent) for class I and six different class II genes. MHC class I genes are called HLA -A, -B, and -C; those for class II genes are called HLA-DP, -DQ, and -DR. All these loci express a high degree of polymorphism and each year many new alleles are discovered decreasing the likelihood of two unrelated individual having identical class I and II proteins. A complete characterization of closely matched alleles between two different individuals help for transplantation rejection. Following an organ transplantation the patient has to be carefully monitored for complications including infection and rejection. Integrated Gulf Biosystems (IGB) offers a whole range of solutions from multiple principals for HLA typing ranging from Serology based matching to using Next Generation Sequencing (NGS) methods, we also offer a range of post-transplant monitoring products.

Clinical Oncology

Human leukocyte antigen (HLA) is a protein-or marker-found on most cells in humans and is used to match with a donor for organ, bone marrow or cord blood transplants. HLAs correspond to major histocompatibility complex (MHC) proteins in humans with six genes (three from each parent) for class I and six different class II genes. MHC class I genes are called HLA -A, -B, and -C; those for class II genes are called HLA-DP, -DQ, and -DR. All these loci express a high degree of polymorphism and each year many new alleles are discovered decreasing the likelihood of two unrelated individual having identical class I and II proteins. 

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